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Genome-wide siRNA screen identifies UNC50 as a regulator of Shiga toxin 2 trafficking
Shiga toxins 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol. Early endosome-to-Golgi transport allows the toxins to evade degradation in lysosomes. Targeting this trafficking step has therapeutic promise, but the mechanism of trafficking for the more potent toxin STx2 is...
Guardat en:
| Publicat a: | J Cell Biol |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5626549/ https://ncbi.nlm.nih.gov/pubmed/28883040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201704015 |
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