DNA repair factor RAD18 and DNA polymerase Polκ confer tolerance of oncogenic DNA replication stress

The mechanisms by which neoplastic cells tolerate oncogene-induced DNA replication stress are poorly understood. Cyclin-dependent kinase 2 (CDK2) is a major mediator of oncogenic DNA replication stress. In this study, we show that CDK2-inducing stimuli (including Cyclin E overexpression, oncogenic R...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Yang, Yang, Gao, Yanzhe, Mutter-Rottmayer, Liz, Zlatanou, Anastasia, Durando, Michael, Ding, Weimin, Wyatt, David, Ramsden, Dale, Tanoue, Yuki, Tateishi, Satoshi, Vaziri, Cyrus
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5626543/
https://ncbi.nlm.nih.gov/pubmed/28835467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201702006
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