Structure-Based Design of Hepatitis C Virus Vaccines That Elicit Neutralizing Antibody Responses to a Conserved Epitope

Despite recent advances in therapeutic options, hepatitis C virus (HCV) remains a severe global disease burden, and a vaccine can substantially reduce its incidence. Due to its extremely high sequence variability, HCV can readily escape the immune response; thus, an effective vaccine must target con...

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Bibliographische Detailangaben
Veröffentlicht in:J Virol
Hauptverfasser: Pierce, Brian G., Boucher, Elisabeth N., Piepenbrink, Kurt H., Ejemel, Monir, Rapp, Chelsea A., Thomas, William D., Sundberg, Eric J., Weng, Zhiping, Wang, Yang
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Vaccines and Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625506/
https://ncbi.nlm.nih.gov/pubmed/28794021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01032-17
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