Identification of an HIV-1 Clade A Envelope That Exhibits Broad Antigenicity and Neutralization Sensitivity and Elicits Antibodies Targeting Three Distinct Epitopes

Broadly neutralizing antibodies (bNAbs) PG9 and PG16 were isolated from an International AIDS Vaccine Initiative (IAVI) Protocol G subject infected with human immunodeficiency virus type 1 (HIV-1) clade A. Both antibodies are highly potent and neutralize greater than 70% of viruses tested. We sought...

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Detalhes bibliográficos
Principais autores: Hoffenberg, Simon, Powell, Rebecca, Carpov, Alexei, Wagner, Denise, Wilson, Aaron, Kosakovsky Pond, Sergei, Lindsay, Ross, Arendt, Heather, DeStefano, Joanne, Phogat, Sanjay, Poignard, Pascal, Fling, Steven P., Simek, Melissa, LaBranche, Celia, Montefiori, David, Wrin, Terri, Phung, Pham, Burton, Dennis, Koff, Wayne, King, C. Richter, Parks, Christopher L., Caulfield, Michael J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648150/
https://ncbi.nlm.nih.gov/pubmed/23468492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02827-12
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