Mutations in the E2 Glycoprotein and the 3′ Untranslated Region Enhance Chikungunya Virus Virulence in Mice

Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes debilitating musculoskeletal pain and inflammation and can persist for months to years after acute infection. Although studies of humans and experimentally infected animals suggest that CHIKV infection persists in musculoskel...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Hawman, David W., Carpentier, Kathryn S., Fox, Julie M., May, Nicholas A., Sanders, Wes, Montgomery, Stephanie A., Moorman, Nathaniel J., Diamond, Michael S., Morrison, Thomas E.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2017
Sujets:
Pathogenesis and Immunity
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625495/
https://ncbi.nlm.nih.gov/pubmed/28747508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00816-17
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