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Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease

Huntington's disease (HD) is an autosomal dominant, neurodegenerative disorder characterized by motor as well as nonmotor symptoms for which there is currently no cure. The Q175 mouse model of HD recapitulates many of the symptoms identified in HD patients including disruptions of the sleep/wak...

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Detalhes bibliográficos
Publicado no:Pharmacol Res Perspect
Main Authors: Whittaker, Daniel S., Wang, Huei‐Bin, Loh, Dawn H., Cachope, Roger, Colwell, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625154/
https://ncbi.nlm.nih.gov/pubmed/28971617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prp2.344
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