The Rev1 interacting region (RIR) motif in the scaffold protein XRCC1 mediates a low-affinity interaction with polynucleotide kinase/phosphatase (PNKP) during DNA single-strand break repair

The scaffold protein X-ray repair cross-complementing 1 (XRCC1) interacts with multiple enzymes involved in DNA base excision repair and single-strand break repair (SSBR) and is important for genetic integrity and normal neurological function. One of the most important interactions of XRCC1 is that...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Breslin, Claire, Mani, Rajam S., Fanta, Mesfin, Hoch, Nicolas, Weinfeld, Michael, Caldecott, Keith W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5625035/
https://ncbi.nlm.nih.gov/pubmed/28821613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.806638
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