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A Simple PB/LIE Free Energy Function Accurately Predicts the Peptide Binding Specificity of the Tiam1 PDZ Domain

PDZ domains generally bind short amino acid sequences at the C-terminus of target proteins, and short peptides can be used as inhibitors or model ligands. Here, we used experimental binding assays and molecular dynamics simulations to characterize 51 complexes involving the Tiam1 PDZ domain and to t...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Mol Biosci
Prif Awduron: Panel, Nicolas, Sun, Young Joo, Fuentes, Ernesto J., Simonson, Thomas
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623046/
https://ncbi.nlm.nih.gov/pubmed/29018806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2017.00065
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