Hexokinases link DJ-1 to the PINK1/parkin pathway

BACKGROUND: Early onset Parkinson’s disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but the function of DJ-1 and how it relates to PINK1 and parkin is poorly understood. METHODS: A series of unbiased high-content s...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Hauser, David N., Mamais, Adamantios, Conti, Melissa M., Primiani, Christopher T., Kumaran, Ravindran, Dillman, Allissa A., Langston, Rebekah G., Beilina, Alexandra, Garcia, Joseph H., Diaz-Ruiz, Alberto, Bernier, Michel, Fiesel, Fabienne C., Hou, Xu, Springer, Wolfdieter, Li, Yan, de Cabo, Rafael, Cookson, Mark R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622528/
https://ncbi.nlm.nih.gov/pubmed/28962651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0212-x
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