The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice1,2,3

Mutations in the DJ-1 gene cause autosomal recessive parkinsonism in humans. Several mouse models of DJ-1 deficiency have been developed, but they do not have dopaminergic neuron cell death in the substantia nigra pars compacta (SNpc). Mitochondrial DNA (mtDNA) damage occurs frequently in the aged h...

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Detalhes bibliográficos
Publicado no:eNeuro
Main Authors: Hauser, David N., Primiani, Christopher T., Langston, Rebekah G., Kumaran, Ravindran, Cookson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Negative Results
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4586922/
https://ncbi.nlm.nih.gov/pubmed/26464968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/ENEURO.0075-14.2015
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