Redundancy between nucleases required for homologous recombination promotes PARP inhibitor resistance in the eukaryotic model organism Dictyostelium

ADP-ribosyltransferases promote repair of DNA single strand breaks and disruption of this pathway by Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPi) is toxic to cells with defects in homologous recombination (HR). Here, we show that this relationship is conserved in the simple eukaryote Dictyo...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Kolb, Anna-Lena, Gunn, Alasdair R., Lakin, Nicholas D.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5622368/
https://ncbi.nlm.nih.gov/pubmed/28973445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx639
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