Pharmacologic HIV-1 Nef blockade promotes CD8 T cell–mediated elimination of latently HIV-1–infected cells in vitro

Eradication of the HIV-1 latent reservoir represents the current paradigm to developing a cure for AIDS. HIV-1 has evolved multiple mechanisms to evade CD8 T cell responses, including HIV-1 Nef–mediated downregulation of MHC-I from the surface of infected cells. Nef transcripts and protein are detec...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Mujib, Shariq, Saiyed, Aamir, Fadel, Saleh, Bozorgzad, Ardalan, Aidarus, Nasra, Yue, Feng Yun, Benko, Erika, Kovacs, Colin, Emert-Sedlak, Lori A., Smithgall, Thomas E., Ostrowski, Mario A.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2017
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5621880/
https://ncbi.nlm.nih.gov/pubmed/28878119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.93684
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