SAMHD1 acetylation enhances its deoxynucleotide triphosphohydrolase activity and promotes cancer cell proliferation

SAM domain and HD domain containing protein 1 (SAMHD1) is a deoxynucleotide triphosphohydrolase (dNTPase) that inhibits retroviruses by depleting intracellular deoxynucleotide triphosphates (dNTPs) in non-cycling myeloid cells. Although SAMHD1 is expressed ubiquitously throughout the human body, the...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Lee, Eun Ji, Seo, Ji Hae, Park, Ji-Hyeon, Vo, Tam Thuy Lu, An, Sunho, Bae, Sung-Jin, Le, Hoang, Lee, Hye Shin, Wee, Hee-Jun, Lee, Danbi, Chung, Young-Hwa, Kim, Jeong A., Jang, Myoung-Kuk, Ryu, Soo Hyung, Yu, Ensil, Jang, Se Hwan, Park, Zee Yong, Kim, Kyu-Won
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620274/
https://ncbi.nlm.nih.gov/pubmed/28978134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19704
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