Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

The SAMHD1 protein is an HIV-1 restriction factor that is targeted by the HIV-2 accessory protein Vpx in myeloid lineage cells. Mutations in the SAMHD1 gene cause Aicardi-Goutières syndrome, a genetic disease that mimics congenital viral infection. To determine the physiological function of the SAMH...

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Hlavní autoři: Powell, Rebecca D., Holland, Paul J., Hollis, Thomas, Perrino, Fred W.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243528/
https://ncbi.nlm.nih.gov/pubmed/22069334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C111.317628
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