Nuclease Activity of the Human SAMHD1 Protein Implicated in the Aicardi-Goutières Syndrome and HIV-1 Restriction

The human HD domain protein SAMHD1 is implicated in the Aicardi-Goutières autoimmune syndrome and in the restriction of HIV-1 replication in myeloid cells. Recently, this protein has been shown to possess dNTP triphosphatase activity, which is proposed to inhibit HIV-1 replication and the autoimmune...

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Bibliographic Details
Main Authors: Beloglazova, Natalia, Flick, Robert, Tchigvintsev, Anatoli, Brown, Greg, Popovic, Ana, Nocek, Boguslaw, Yakunin, Alexander F.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3605629/
https://ncbi.nlm.nih.gov/pubmed/23364794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.431148
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