Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs)

Here, we developed a new synthetic lethal strategy for further optimizing the eradication of cancer stem cells (CSCs). Briefly, we show that chronic treatment with the FDA-approved antibiotic Doxycycline effectively reduces cellular respiration, by targeting mitochondrial protein translation. The ex...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: De Francesco, Ernestina Marianna, Bonuccelli, Gloria, Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5620172/
https://ncbi.nlm.nih.gov/pubmed/28978032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18428
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