Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypoxia-induced propagation of CSCs. More specifically,...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: De Francesco, Ernestina Marianna, Maggiolini, Marcello, Tanowitz, Herbert B., Sotgia, Federica, Lisanti, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593549/
https://ncbi.nlm.nih.gov/pubmed/28915578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18445
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