Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypoxia-induced propagation of CSCs. More specifically,...

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Detalles Bibliográficos
Publicado en:Oncotarget
Main Authors: De Francesco, Ernestina Marianna, Maggiolini, Marcello, Tanowitz, Herbert B., Sotgia, Federica, Lisanti, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado: Impact Journals LLC 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5593549/
https://ncbi.nlm.nih.gov/pubmed/28915578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18445
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