MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Cystic fibrosis results from reduced cystic fibrosis transmembrane conductance regulator protein activity leading to defective epithelial ion transport. Ca(2+)-activated Cl(−) channels mediate physiological functions independently of cystic fibrosis transmembrane conductance regulator. Anoctamin 1 (...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Sonneville, Florence, Ruffin, Manon, Coraux, Christelle, Rousselet, Nathalie, Le Rouzic, Philippe, Blouquit-Laye, Sabine, Corvol, Harriet, Tabary, Olivier
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617894/
https://ncbi.nlm.nih.gov/pubmed/28955034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00813-z
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