MicroRNA-9 downregulates the ANO1 chloride channel and contributes to cystic fibrosis lung pathology

Cystic fibrosis results from reduced cystic fibrosis transmembrane conductance regulator protein activity leading to defective epithelial ion transport. Ca(2+)-activated Cl(−) channels mediate physiological functions independently of cystic fibrosis transmembrane conductance regulator. Anoctamin 1 (...

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Vydáno v:Nat Commun
Hlavní autoři: Sonneville, Florence, Ruffin, Manon, Coraux, Christelle, Rousselet, Nathalie, Le Rouzic, Philippe, Blouquit-Laye, Sabine, Corvol, Harriet, Tabary, Olivier
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617894/
https://ncbi.nlm.nih.gov/pubmed/28955034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00813-z
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