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Genetic variation in CFTR and modifier loci may modulate Cystic Fibrosis disease severity
In patients with cystic fibrosis (CF), genetic variants within and outside the CFTR locus contribute to the variability of the disease severity. CFTR transcription is tightly regulated by cis-regulatory elements (CREs) that control the three-dimensional structure of the locus, chromatin accessibilit...
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| Publicado no: | J Cyst Fibros |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7036019/ https://ncbi.nlm.nih.gov/pubmed/31734115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2019.11.001 |
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