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Genetic variation in CFTR and modifier loci may modulate Cystic Fibrosis disease severity
In patients with cystic fibrosis (CF), genetic variants within and outside the CFTR locus contribute to the variability of the disease severity. CFTR transcription is tightly regulated by cis-regulatory elements (CREs) that control the three-dimensional structure of the locus, chromatin accessibilit...
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| Pubblicato in: | J Cyst Fibros |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7036019/ https://ncbi.nlm.nih.gov/pubmed/31734115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2019.11.001 |
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