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C1-Ten is a PTPase of nephrin, regulating podocyte hypertrophy through mTORC1 activation
Hypertrophy is a prominent feature of damaged podocytes in diabetic kidney disease (DKD). mTORC1 hyperactivation leads to podocyte hypertrophy, but the detailed mechanism of how mTORC1 activation occurs under pathological conditions is not completely known. Moreover, reduced nephrin tyrosine phospho...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617844/ https://ncbi.nlm.nih.gov/pubmed/28955049 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12382-8 |
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