Intraductal cisplatin treatment in a BRCA-associated breast cancer mouse model attenuates tumor development but leads to systemic tumors in aged female mice

BRCA deficiency predisposes to the development of invasive breast cancer. In BRCA mutation carriers this risk can increase up to 80%. Currently, bilateral prophylactic mastectomy and prophylactic bilateral salpingo-oophorectomy are the only preventive, albeit radical invasive strategies to prevent b...

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Udgivet i:Oncotarget
Main Authors: de Groot, Jolien S., van Diest, Paul J., van Amersfoort, Miranda, Vlug, Eva J., Pan, Xiaojuan, ter Hoeve, Natalie D., Rosing, Hilde, Beijnen, Jos H., Youssef, Sameh A., de Bruin, Alain, Jonkers, Jos, van der Wall, Elsken, Derksen, Patrick W.B.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
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Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617383/
https://ncbi.nlm.nih.gov/pubmed/28977823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.18490
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