Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test for the detection of pancreatic ductal adenocarcinoma. We combined blood tests for KRAS gene mutations with carefully thresholded protein bioma...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Cohen, Joshua D., Javed, Ammar A., Thoburn, Christopher, Wong, Fay, Tie, Jeanne, Gibbs, Peter, Schmidt, C. Max, Yip-Schneider, Michele T., Allen, Peter J., Schattner, Mark, Brand, Randall E., Singhi, Aatur D., Petersen, Gloria M., Hong, Seung-Mo, Kim, Song Cheol, Falconi, Massimo, Doglioni, Claudio, Weiss, Matthew J., Ahuja, Nita, He, Jin, Makary, Martin A., Maitra, Anirban, Hanash, Samir M., Dal Molin, Marco, Wang, Yuxuan, Li, Lu, Ptak, Janine, Dobbyn, Lisa, Schaefer, Joy, Silliman, Natalie, Popoli, Maria, Goggins, Michael G., Hruban, Ralph H., Wolfgang, Christopher L., Klein, Alison P., Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Lennon, Anne Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617273/
https://ncbi.nlm.nih.gov/pubmed/28874546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704961114
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