Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers

The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test for the detection of pancreatic ductal adenocarcinoma. We combined blood tests for KRAS gene mutations with carefully thresholded protein bioma...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Cohen, Joshua D., Javed, Ammar A., Thoburn, Christopher, Wong, Fay, Tie, Jeanne, Gibbs, Peter, Schmidt, C. Max, Yip-Schneider, Michele T., Allen, Peter J., Schattner, Mark, Brand, Randall E., Singhi, Aatur D., Petersen, Gloria M., Hong, Seung-Mo, Kim, Song Cheol, Falconi, Massimo, Doglioni, Claudio, Weiss, Matthew J., Ahuja, Nita, He, Jin, Makary, Martin A., Maitra, Anirban, Hanash, Samir M., Dal Molin, Marco, Wang, Yuxuan, Li, Lu, Ptak, Janine, Dobbyn, Lisa, Schaefer, Joy, Silliman, Natalie, Popoli, Maria, Goggins, Michael G., Hruban, Ralph H., Wolfgang, Christopher L., Klein, Alison P., Tomasetti, Cristian, Papadopoulos, Nickolas, Kinzler, Kenneth W., Vogelstein, Bert, Lennon, Anne Marie
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617273/
https://ncbi.nlm.nih.gov/pubmed/28874546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704961114
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