Assessing aneuploidy with repetitive element sequencing

We report a sensitive PCR-based assay called Repetitive Element AneupLoidy Sequencing System (RealSeqS) that can detect aneuploidy in samples containing as little as 3 pg of DNA. Using a single primer pair, we amplified ∼350,000 amplicons distributed throughout the genome. Aneuploidy was detected in...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Douville, Christopher, Cohen, Joshua D., Ptak, Janine, Popoli, Maria, Schaefer, Joy, Silliman, Natalie, Dobbyn, Lisa, Schoen, Robert E., Tie, Jeanne, Gibbs, Peter, Goggins, Michael, Wolfgang, Christopher L., Wang, Tian-Li, Shih, Ie-Ming, Karchin, Rachel, Lennon, Anne Marie, Hruban, Ralph H., Tomasetti, Cristian, Bettegowda, Chetan, Kinzler, Kenneth W., Papadopoulos, Nickolas, Vogelstein, Bert
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060727/
https://ncbi.nlm.nih.gov/pubmed/32075918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1910041117
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