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Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions
Caspase-6 is critical to the neurodegenerative pathways of Alzheimer’s, Huntington’s, and Parkinson’s diseases and has been identified as a potential molecular target for treatment of neurodegeneration. Thus, understanding the global and regional changes in dynamics and conformation provides insight...
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| Publicat a: | Proc Natl Acad Sci U S A |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5617271/ https://ncbi.nlm.nih.gov/pubmed/28864531 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1704640114 |
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