DNA replication stress restricts ribosomal DNA copy number

Ribosomal RNAs (rRNAs) in budding yeast are encoded by ~100–200 repeats of a 9.1kb sequence arranged in tandem on chromosome XII, the ribosomal DNA (rDNA) locus. Copy number of rDNA repeat units in eukaryotic cells is maintained far in excess of the requirement for ribosome biogenesis. Despite the i...

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Bibliographic Details
Published in:PLoS Genet
Main Authors: Salim, Devika, Bradford, William D., Freeland, Amy, Cady, Gillian, Wang, Jianmin, Pruitt, Steven C., Gerton, Jennifer L.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2017
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5617229/
https://ncbi.nlm.nih.gov/pubmed/28915237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007006
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