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Ribosomal DNA copy number loss and sequence variation in cancer

Ribosomal DNA is one of the most variable regions in the human genome with respect to copy number. Despite the importance of rDNA for cellular function, we know virtually nothing about what governs its copy number, stability, and sequence in the mammalian genome due to challenges associated with map...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Xu, Baoshan, Li, Hua, Perry, John M., Singh, Vijay Pratap, Unruh, Jay, Yu, Zulin, Zakari, Musinu, McDowell, William, Li, Linheng, Gerton, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5480814/
https://ncbi.nlm.nih.gov/pubmed/28640831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006771
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