Ultrasensitive Measurement of Ca(2+) Influx into Lipid Vesicles Induced by Protein Aggregates

To quantify and characterize the potentially toxic protein aggregates associated with neurodegenerative diseases, a high‐throughput assay based on measuring the extent of aggregate‐induced Ca(2+) entry into individual lipid vesicles has been developed. This approach was implemented by tethering vesi...

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Veröffentlicht in:Angew Chem Int Ed Engl
Hauptverfasser: Flagmeier, Patrick, De, Suman, Wirthensohn, David C., Lee, Steven F., Vincke, Cécile, Muyldermans, Serge, Knowles, Tuomas P. J., Gandhi, Sonia, Dobson, Christopher M., Klenerman, David
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Communications
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5615231/
https://ncbi.nlm.nih.gov/pubmed/28474754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201700966
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