Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates

Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrP(Sc). This effect has been associated with differences in foldi...

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Udgivet i:PLoS Pathog
Main Authors: Groveman, Bradley R., Raymond, Gregory J., Campbell, Katrina J., Race, Brent, Raymond, Lynne D., Hughson, Andrew G., Orrú, Christina D., Kraus, Allison, Phillips, Katie, Caughey, Byron
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614645/
https://ncbi.nlm.nih.gov/pubmed/28910420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006623
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