Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates

Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrP(Sc). This effect has been associated with differences in foldi...

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Publicado en:PLoS Pathog
Autores principales: Groveman, Bradley R., Raymond, Gregory J., Campbell, Katrina J., Race, Brent, Raymond, Lynne D., Hughson, Andrew G., Orrú, Christina D., Kraus, Allison, Phillips, Katie, Caughey, Byron
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614645/
https://ncbi.nlm.nih.gov/pubmed/28910420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006623
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