Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates

Mammalian prion structures and replication mechanisms are poorly understood. Most synthetic recombinant prion protein (rPrP) amyloids prepared without cofactors are non-infectious or much less infectious than bona fide tissue-derived PrP(Sc). This effect has been associated with differences in foldi...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Groveman, Bradley R., Raymond, Gregory J., Campbell, Katrina J., Race, Brent, Raymond, Lynne D., Hughson, Andrew G., Orrú, Christina D., Kraus, Allison, Phillips, Katie, Caughey, Byron
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614645/
https://ncbi.nlm.nih.gov/pubmed/28910420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006623
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