Structural insights into substrate selectivity of ribosomal RNA methyltransferase RlmCD

RlmCD has recently been identified as the S-adenosyl methionine (SAM)-dependent methyltransferase responsible for the formation of m(5)U at U747 and U1939 of 23S ribosomal RNA in Streptococcus pneumoniae. In this research, we determine the high-resolution crystal structures of apo-form RlmCD and its...

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Veröffentlicht in:PLoS One
Hauptverfasser: Jiang, Yiyang, Li, Fudong, Wu, Jihui, Shi, Yunyu, Gong, Qingguo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5614603/
https://ncbi.nlm.nih.gov/pubmed/28949991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0185226
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