Polyglutamine tracts regulate autophagy

Expansions of polyglutamine (polyQ) tracts in different proteins cause 9 neurodegenerative conditions, such as Huntington disease and various ataxias. However, many normal mammalian proteins contain shorter polyQ tracts. As these are frequently conserved in multiple species, it is likely that some o...

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Veröffentlicht in:Autophagy
Hauptverfasser: Ashkenazi, Avraham, Bento, Carla F., Ricketts, Thomas, Vicinanza, Mariella, Siddiqi, Farah, Pavel, Mariana, Squitieri, Ferdinando, Hardenberg, Maarten C., Imarisio, Sara, Menzies, Fiona M., Rubinsztein, David C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
Schlagworte:
Autophagic Puncta
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612341/
https://ncbi.nlm.nih.gov/pubmed/28722507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2017.1336278
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