Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor

Complement C1q is part of the C1 macromolecular complex that mediates the classical complement activation pathway: a major arm of innate immune defense. C1q is composed of A, B, and C chains that require post-translational prolyl 4-hydroxylation of their N-terminal collagen-like domain to enable the...

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Detalles Bibliográficos
Publicado en:Kidney Int
Autores principales: Kiriakidis, Serafim, Hoer, Simon S., Burrows, Natalie, Biddlecome, Gloria, Khan, Moddasar N., Thinnes, Cyrille C., Schofield, Christopher J., Rogers, Norma, Botto, Marina, Paleolog, Ewa, Maxwell, Patrick H.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2017
Materias:
Basic Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612014/
https://ncbi.nlm.nih.gov/pubmed/28506759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.03.008
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