Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases

Post-translational ribosomal protein hydroxylation is catalyzed by 2-oxoglutarate (2OG) and ferrous iron dependent oxygenases, and occurs in prokaryotes and eukaryotes. OGFOD1 catalyzes trans-3 prolyl hydroxylation at Pro62 of the small ribosomal subunit protein uS12 (RPS23) and is conserved from ye...

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Bibliographic Details
Published in:Structure
Main Authors: Horita, Shoichiro, Scotti, John S., Thinnes, Cyrille, Mottaghi-Taromsari, Yousef S., Thalhammer, Armin, Ge, Wei, Aik, WeiShen, Loenarz, Christoph, Schofield, Christopher J., McDonough, Michael A.
Format: Artigo
Language:Inglês
Published: Cell Press 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396695/
https://ncbi.nlm.nih.gov/pubmed/25728928
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2015.01.014
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