Mutation Detection in Patients With Advanced Cancer by Universal Sequencing of Cancer-Related Genes in Tumor and Normal DNA vs Guideline-Based Germline Testing

IMPORTANCE: Guidelines for cancer genetic testing based on family history may miss clinically actionable genetic changes with established implications for cancer screening or prevention. OBJECTIVE: To determine the proportion and potential clinical implications of inherited variants detected using s...

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Detalhes bibliográficos
Publicado no:JAMA
Main Authors: Mandelker, Diana, Zhang, Liying, Kemel, Yelena, Stadler, Zsofia K., Joseph, Vijai, Zehir, Ahmet, Pradhan, Nisha, Arnold, Angela, Walsh, Michael F., Li, Yirong, Balakrishnan, Anoop R., Syed, Aijazuddin, Prasad, Meera, Nafa, Khedoudja, Carlo, Maria I., Cadoo, Karen A., Sheehan, Meg, Fleischut, Megan H., Salo-Mullen, Erin, Trottier, Magan, Lipkin, Steven M., Lincoln, Anne, Mukherjee, Semanti, Ravichandran, Vignesh, Cambria, Roy, Galle, Jesse, Abida, Wassim, Arcila, Marcia E., Benayed, Ryma, Shah, Ronak, Yu, Kenneth, Bajorin, Dean F., Coleman, Jonathan A., Leach, Steven D., Lowery, Maeve A., Garcia-Aguilar, Julio, Kantoff, Philip W., Sawyers, Charles L., Dickler, Maura N., Saltz, Leonard, Motzer, Robert J., O’Reilly, Eileen M., Scher, Howard I., Baselga, Jose, Klimstra, David S., Solit, David B., Hyman, David M., Berger, Michael F., Ladanyi, Marc, Robson, Mark E., Offit, Kenneth
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5611881/
https://ncbi.nlm.nih.gov/pubmed/28873162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2017.11137
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