Podocyte-specific JAK2 overexpression worsens diabetic kidney disease in mice

Activation of the JAK-STAT signaling has been implicated in the pathogenesis of diabetic kidney disease. An increased expression of JAK-STAT genes was found in kidney glomerular cells, including podocytes, in patients with early diabetic kidney disease. However, it is not known whether increased exp...

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Publicat a:Kidney Int
Autors principals: Zhang, Hongyu, Nair, Viji, Saha, Jharna, Atkins, Kevin B., Hodgin, Jeffrey B., Saunders, Thomas L., Myers, Martin G., Werner, Thomas, Kretzler, Matthias, Brosius, Frank C.
Format: Artigo
Idioma:Inglês
Publicat: 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610635/
https://ncbi.nlm.nih.gov/pubmed/28554737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2017.03.027
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