Podocyte-specific overexpression of GLUT1 surprisingly reduces mesangial matrix expansion in diabetic nephropathy in mice

Increased expression of the facilitative glucose transporter, GLUT1, leads to glomerulopathy that resembles diabetic nephropathy, whereas prevention of enhanced GLUT1 expression retards nephropathy. While many of the GLUT1-mediated effects are likely due to mesangial cell effects, we hypothesized th...

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Hlavní autoři: Zhang, Hongyu, Schin, MaryLee, Saha, Jharna, Burke, Kathleen, Holzman, Lawrence B., Filipiak, Wanda, Saunders, Thomas, Xiang, Minghui, Heilig, Charles W., Brosius, Frank C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2904178/
https://ncbi.nlm.nih.gov/pubmed/20375116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00021.2010
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