A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

The RNase H (RNH) function of HIV-1 reverse transcriptase (RT) plays an essential part in the viral life cycle. We report the characterization of YLC2-155, a 2-hydroxyisoquinoline-1,3-dione (HID)-based active-site RNH inhibitor. YLC2-155 inhibits both polymerase (50% inhibitory concentration [IC(50)...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Kirby, Karen A., Myshakina, Nataliya A., Christen, Martin T., Chen, Yue-Lei, Schmidt, Hilary A., Huber, Andrew D., Xi, Zhaoyong, Kim, Seongmi, Rao, Rohit K., Kramer, Skyler T., Yang, Qiongying, Singh, Kamalendra, Parniak, Michael A., Wang, Zhengqiang, Ishima, Rieko, Sarafianos, Stefan G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610509/
https://ncbi.nlm.nih.gov/pubmed/28760905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01351-17
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