A 2-Hydroxyisoquinoline-1,3-Dione Active-Site RNase H Inhibitor Binds in Multiple Modes to HIV-1 Reverse Transcriptase

The RNase H (RNH) function of HIV-1 reverse transcriptase (RT) plays an essential part in the viral life cycle. We report the characterization of YLC2-155, a 2-hydroxyisoquinoline-1,3-dione (HID)-based active-site RNH inhibitor. YLC2-155 inhibits both polymerase (50% inhibitory concentration [IC(50)...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Kirby, Karen A., Myshakina, Nataliya A., Christen, Martin T., Chen, Yue-Lei, Schmidt, Hilary A., Huber, Andrew D., Xi, Zhaoyong, Kim, Seongmi, Rao, Rohit K., Kramer, Skyler T., Yang, Qiongying, Singh, Kamalendra, Parniak, Michael A., Wang, Zhengqiang, Ishima, Rieko, Sarafianos, Stefan G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2017
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610509/
https://ncbi.nlm.nih.gov/pubmed/28760905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01351-17
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