A Human Biofilm-Disrupting Monoclonal Antibody Potentiates Antibiotic Efficacy in Rodent Models of both Staphylococcus aureus and Acinetobacter baumannii Infections

Many serious bacterial infections are antibiotic refractory due to biofilm formation. A key structural component of biofilm is extracellular DNA, which is stabilized by bacterial proteins, including those from the DNABII family. TRL1068 is a high-affinity human monoclonal antibody against a DNABII e...

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Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Xiong, Yan Q., Estellés, Angeles, Li, L., Abdelhady, W., Gonzales, R., Bayer, Arnold S., Tenorio, Edgar, Leighton, Anton, Ryser, Stefan, Kauvar, Lawrence M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2017
Schlagworte:
Experimental Therapeutics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610488/
https://ncbi.nlm.nih.gov/pubmed/28717038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00904-17
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