Disruption of Biofilm Formation by the Human Pathogen Acinetobacter baumannii Using Engineered Quorum-Quenching Lactonases

Acinetobacter baumannii is a major human pathogen associated with multidrug-resistant nosocomial infections; its virulence is attributed to quorum-sensing-mediated biofilm formation, and disruption of biofilm formation is an attractive antivirulence strategy. Here, we report the first successful dem...

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Bibliographic Details
Main Authors: Chow, Jeng Yeong, Yang, Yuanyong, Tay, Song Buck, Chua, Kim Lee, Yew, Wen Shan
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2014
Subjects:
Experimental Therapeutics
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3957888/
https://ncbi.nlm.nih.gov/pubmed/24379199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02410-13
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