High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals

We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs) from peripheral blood mononuclear cells (PBMC) of healthy human donors. The cells that express these mAbs are rare, present at a frequency of less than one per 10(5) memory B-cells. Using our...

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Publicat a:PLoS One
Autors principals: Ryser, Stefan, Estellés, Angeles, Tenorio, Edgar, Kauvar, Lawrence M., Gishizky, Mikhail L.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5517007/
https://ncbi.nlm.nih.gov/pubmed/28723950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181464
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