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Distinct Solubility and Cytotoxicity Regimes of Paclitaxel-Loaded Cationic Liposomes at Low and High Drug Content Revealed by Kinetic Phase Behavior and Cancer Cell Viability Studies

Lipid-based particles are used worldwide in clinical trials as carriers of hydrophobic paclitaxel (PTXL) for cancer chemotherapy, albeit with little improvement over the standard-of-care. Improving efficacy requires an understanding of intramembrane interactions between PTXL and lipids to enhance PT...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Steffes, Victoria M., Murali, Meena M., Park, Yoonsang, Fletcher, Bretton J., Ewert, Kai K., Safinya, Cyrus R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5610109/
https://ncbi.nlm.nih.gov/pubmed/28889081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2017.08.026
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