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The Role of Cholesterol and Structurally Related Molecules in Enhancing Transfection by Cationic Liposome–DNA Complexes
Motivated by its important role in gene delivery, we have studied the effect of cholesterol and analogs on the transfection efficiency (TE) of lamellar cationic liposome–DNA (CL–DNA) complexes in vitro. Addition of cholesterol to low-transfecting DOTAP/DOPC–DNA complexes increases TE, with 15 mol% c...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2701310/ https://ncbi.nlm.nih.gov/pubmed/19354307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp809000e |
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