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Conformational selection in amyloid-based immunotherapy: survey of crystal structures of antibody-amyloid complexes
BACKGROUND: The dominant feature in neurodegenerative diseases is protein aggregations that lead to neuronal loss. Immunotherapies using antibodies or antibody fragments to target the aggregations are a highly perused approach. The molecular mechanisms underlying the amyloid-based immunotherapy are...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5610039/ https://ncbi.nlm.nih.gov/pubmed/27266343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2016.05.040 |
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