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Protein dynamics and conformational selection in bidirectional signal transduction
Protein conformational dynamics simultaneously allow promiscuity and specificity in binding. The multiple conformations of the free EphA4 ligand-binding domain observed in two new EphA4 crystal structures provide a unique insight into the conformational dynamics of EphA4 and its signaling pathways....
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3266202/ https://ncbi.nlm.nih.gov/pubmed/22277130 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-2 |
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