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Mechanisms of recognition of amyloid-β (Aβ) monomer, oligomer, and fibril by homologous antibodies

Alzheimer's disease is one of the most devastating neurodegenerative diseases without effective therapies. Immunotherapy is a promising approach, but amyloid antibody structural information is limited. Here we simulate the recognition of monomeric, oligomeric, and fibril amyloid-β (Aβ) by three...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Zhao, Jun, Nussinov, Ruth, Ma, Buyong
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5672054/
https://ncbi.nlm.nih.gov/pubmed/28924036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.801514
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