Set2 Methyltransferase Facilitates DNA Replication and Promotes Genotoxic Stress Responses through MBF-Dependent Transcription

Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation in facilitating DNA replication and the transcriptional responses to both replication stress a...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Pai, Chen-Chun, Kishkevich, Anastasiya, Deegan, Rachel S., Keszthelyi, Andrea, Folkes, Lisa, Kearsey, Stephen E., De León, Nagore, Soriano, Ignacio, de Bruin, Robertus Antonius Maria, Carr, Antony M., Humphrey, Timothy C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cell Press 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608972/
https://ncbi.nlm.nih.gov/pubmed/28903048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.08.058
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